Novo Nordisk Norditropin FlexPro 1 vial (1x 45 IU)

HGH – human growth hormone

Human growth hormone, or GH, is a vital substance produced by the anterior pituitary gland, playing a critical role in growth and development. Its release begins at birth, peaking during late adolescence, then progressively declines post-40. For over four decades, GH has been utilized therapeutically for various medical conditions, yet in recent years, it has gained immense popularity among adults seeking to combat aging, adolescents aspiring for better physiques, and athletes striving for enhanced performance. Among athletes, the abuse of growth hormone is alarmingly high, ranking within the top three substances misused.

What is Human Growth Hormone?

Human growth hormone, commonly referred to as HGH or hGH, stimulates cell production, growth, and metabolism within the body. Secreted from the anterior pituitary located at the skull’s base, GH works alongside other hormones to foster proper growth and development. GH levels peak during puberty and notably decrease around age 40. Growth hormone is widely accessible through health food stores, spas, and alternative care practitioners, often marketed under various brand names like Genotropin®, Humatrope®, Norditropin®, Nutropin®, Saizen®, and Serostim®.

Pharmacology

Most available GH is synthesized using recombinant DNA technology, with two primary forms: somatropin and somatrem. Both synthetic variants exhibit similar pharmacological effects and, once injected, are indistinguishable from naturally occurring GH. This hormone binds to specific GH receptors in various tissues, prompting diverse cellular responses. GH plays a crucial role in metabolism regulation, fluid balance, and augmentation of skeletal and muscle mass. Its levels typically rise during stress, sleep, and physical activity.

When do GH levels change?

Abnormal GH levels, either deficient or excessive, can lead to significant health issues. Overproduction may result in conditions such as acromegaly—characterized by enlarged extremities and accelerated cellular growth—or pituitary gigantism, which leads to abnormal height increases. Conversely, GH deficiency can lead to various short stature-related health complications.

Approved Clinical Uses of GH

Several FDA-approved injectable preparations of HGH require a prescription from licensed healthcare providers. Initially authorized in 1985 for treating short stature caused by GH deficiency (GHD), GH has since received approval for various conditions linked to GHD, including Prader-Willi syndrome, chronic renal insufficiency, Turner syndrome, idiopathic short stature, and intrauterine growth retardation. It’s also approved for adults experiencing AIDS-related wasting syndrome. Studies indicate that documented benefits of GH treatment may include:

• Enhanced muscle mass and bone density
• Reduced body fat
• Improved cognitive function
• Boosted exercise performance
• Increased cardiovascular endurance

Dosage

GH is administered exclusively via injection—subcutaneously or intramuscularly. Its effects manifest rapidly upon entering the bloodstream. Dosage guidelines remain under research; many healthcare professionals base dosage on body weight, suggesting approximately 0.01-0.1 mg/kg for adults, influenced by the product type and intended use. Current GH formulations come in powder or liquid forms, with the powder requiring solubilization in saline prior to injection.

Side Effects of Growth Hormone

GH usage may lead to several concerning side effects, including:

• Generalized edema
• Carpal tunnel syndrome
• Joint and muscle discomfort
• Neuropathies (e.g., numbness and tingling)
• Elevated blood glucose levels

Prescription Requirements for GH

Authorized use of GH necessitates a physician’s prescription for FDA-approved conditions, although numerous off-label applications exist, such as enhancements for athletic performance and anti-aging. However, the risks associated with altering GH levels often outweigh the benefits, making caution essential for individuals considering treatment.

Potential Risks of Taking GH

Taking GH entails risks, including the possibility of overdose leading to severe conditions like acromegaly. Additionally, GH may inadvertently stimulate the proliferation of unwanted cells, raising concerns over cancers such as leukemia and prostate cancer. Lesser side effects may involve fluid retention, carpal tunnel syndrome, joint pain, and type 2 diabetes. Individuals contemplating GH for anti-aging must thoroughly assess the associated risks.

Off-Label Use

Bodybuilding Off-label applications for GH primarily target anti-aging and bodybuilding. GH ranks among the most frequently abused substances in athletics. Although widely accessible, it is illegal to possess or distribute. Many bodybuilders often combine GH with various other substances, complicating the evaluation of its effectiveness. Its difficulty in detection further contributes to its misuse; nonetheless, the exact number of users remains unclear, with sporadic admissions from athletes regarding its abuse. Monthly costs for GH can range from $500 to $2000, heightening concerns about counterfeit products.

Anti-Aging

GH use has also become popular among those seeking youthful appearances. Despite numerous claims, it is not FDA-approved for anti-aging and lacks evidence supporting its effectiveness in reducing wrinkles or improving skin texture. The surge in GH’ reputation has spawned an unregulated $70 million industry of ineffective alternatives, drawing consumers willing to spend up to $20,000 annually on genuine injections at anti-aging clinics.

Availability

Accessing HGH frequently occurs through illegal channels, with instances of theft from pharmacies and unscrupulous prescribing practices. Imported products from Mexico and Europe also contribute to the black market. Cyberspace pharmacies often operate with lenient standards, frequently dispensing GH without proper patient evaluation. While legitimate administration requires injections, misleading products such as sprays, pills, and topical gels claim to deliver GH, despite poor absorption efficacy.

Limitations of Testing

Detecting synthetic GH in the body proves challenging, with existing methods identifying it only within 48 hours post-injection. This limitation is a known loophole for many athletes who inquire about testing protocols before engaging in illicit drug use.

Sermorelin

Sermorelin, a newer drug potentially counterfeited from Geref, is an analog of growth hormone-releasing hormone (GHRH), prompting GH production by the anterior pituitary. Its effects manifest gradually over 3-4 weeks and carry fewer major side effects compared to GH. However, it is not an adequate substitute for GH in cases of complete deficiency and ranges in cost from $300 to $1000 monthly.

Control Status

The rampant misuse of GH has led to Federal Regulations impacting its distribution. The 1990 Anabolic Steroids Control Act criminalizes possession and distribution, with severe penalties, while a 2007 Senate bill sought to categorize HGH as a Schedule III substance. Currently, GH is classified as a performance-enhancing drug by the World Anti-Doping Agency and the International Olympic Committee, banning its use in sports.