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Tamoxifène - Nolvadex

Nolvadex is a potent non-steroidal medication renowned for its exceptional anti-estrogen effects. By effectively binding to estrogen receptors, it mitigates the impact of estrogen, making it vital in treating specific types of breast cancer in both women and men. Additionally, this medication is pivotal in preventing breast cancer in high-risk women with a history of ductal carcinoma in situ (abnormal breast duct cells). Research continues on its efficacy in various breast cancer types. Often referred to as tamoxifen or tamoxifen citrate.

Indications

Nolvadex is prescribed mainly for metastatic breast cancer in both genders and for premenopausal women facing metastatic breast cancer. It serves as a preferred alternative to surgical procedures (ovary removal) or radiation therapy. Patients with estrogen receptor-positive tumors experience the greatest benefits from Nolvadex treatment. Furthermore, it is recommended as an adjuvant therapy for women post-surgery.

Dosage

Nolvadex comes in 10 mg and 20 mg tablet forms, along with a 10 mg liquid solution. The standard dosage is 20 mg daily, administered orally. It can be taken with or without food. For breast cancer patients, the typical dosage ranges from 20-40 mg/day, with higher doses divided into 1-3 portions, while most bodybuilders start with 20 mg/day, sometimes increasing to 30 mg/day. Continuous use beyond five years is not advised.

Les culturistes

While Nolvadex lacks direct anabolic or androgenic properties, its secondary effects stem from estrogen receptor blockage. By inhibiting estrogen receptors in the hypothalamus, the body perceives a deficiency in this hormone, triggering a surge in Gonadotropins (LH and FSH) that boosts sex hormone synthesis, primarily testosterone. This increase in testosterone contributes to the anabolic and androgenic effects experienced with Nolvadex.

Bodybuilders typically use Nolvadex during the washout period after anabolic steroid cycles since these steroids often suppress testosterone production. While preferred by some, others might choose Arimidex due to the similar effects both medications offer. As Nolvadex blocks estrogen activity, bodybuilders use it to prevent gynecomastia and water retention, resulting in minimal weight gain when used alone. During the washout phase, it helps maintain any weight gained while allowing testes recovery.

Les femmes

Routine prescriptions of Nolvadex are common for women battling metastatic breast cancer. Regardless of the purpose—medical or bodybuilding—women using this drug need regular physician follow-ups. Some side effects to monitor include:

• Saignement vaginal
• Nouvelles masses mammaires
• Lower abdominal fullness
• Douleur dans la région pelvienne
• Gonflement des jambes
• Sudden or gradual shortness of breath
• Changements de vision
• Cycles menstruels irréguliers

Regular breast examinations by healthcare professionals are crucial for all female users of Nolvadex, as even rare complications warrant vigilance. Female bodybuilders must also note that birth control pills may prove ineffective while on Nolvadex.

Effets secondaires généraux

Nolvadex is a remarkably safe drug; extensive use by women reveals that less than 1-3% experience notable side effects, with very few needing to discontinue use. Common side effects in both men and women include:

• Bouffées de chaleur
• Gonflement des jambes
• Altered taste
• Démangeaisons génitales
• Dépression
• Tiredness, dizziness
• Maux de tête
• Perte de cheveux
• Sécheresse vaginale
• Nausées et vomissements
• Douleurs osseuses
• Toux
• Abdominal cramps
• Perte d'appétit

La plupart des effets secondaires disparaissent à l'arrêt du traitement.

Avertissements

Nolvadex may induce hypercalcemia in breast cancer patients shortly after initiation. Cases of uterine cancer linked to Nolvadex usage have also been documented. Moreover, concerns include potential blood clots that could embolize to the lungs, alongside rare occurrences of liver cancer and vision changes.

Surdose

Nolvadex is generally safe, with no reported overdose instances. In cases of high intake, effects may not manifest for 4-6 days. Symptoms may include tremors, an unsteady gait, dizziness, or irregular heart rate, and treatment remains supportive, with no lasting toxicity anticipated.

Détection

This medication is actively monitored by numerous sports organizations. Females with valid prescriptions may take it, yet males with detectable amounts in urine face disqualification from competition. Nolvadex and its metabolites are detectable in urine for 3-4 weeks post last dosage.

Coût

Nolvadex is readily accessible, though pricing varies. Typically, each pill costs about $1.50-$2.00. Generic options made in Asia may be cheaper, but quality and purity are questionable. So far, no counterfeit Nolvadex products have been identified on the market.