Ajanta Apcalis Oral Jelly 1 sachet (20 mg/sachet)

Tadalafil – Cialis

Tadalafil is a renowned phosphodiesterase type 5 (PDE5) inhibitor, widely recognized under the trade names Cialis for erectile dysfunction and Adcirca for pulmonary arterial hypertension treatment.

Characteristics of Tadalafil

Mechanism of Action

• Tadalafil inhibits the enzyme phosphodiesterase type 5, preventing the breakdown of cyclic guanosine monophosphate (cGMP).
• During sexual arousal, the release of nitric oxide enhances cGMP levels.
• This leads to the relaxation of smooth muscles in blood vessels, promoting increased blood flow to the penis, facilitating an erection.

Indications

• Tadalafil is predominantly indicated for the management of erectile dysfunction in men.
• It also treats benign prostatic hyperplasia (BPH) and serves as a treatment for pulmonary arterial hypertension when prescribed as Adcirca.

Onset of Action

• Tadalafil typically takes effect within 30 minutes to 1 hour post-administration.

Duration of Action

• The effects of tadalafil may persist for up to 36 hours, leading to its nickname “weekend pill.”
• This allows men to potentially maintain an erection throughout this period with sexual stimulation.

Dosage

• The recommended dosages for erectile dysfunction vary between 10 mg and 20 mg, taken approximately 30 minutes before intended sexual activity.
• For BPH treatment, a daily dose of 5 mg is commonly prescribed.

Side Effects

• Common adverse effects include headaches, facial flushing, digestive issues (nausea, diarrhea), dizziness, muscle aches, and back pain.
• Serious side effects like sudden vision loss or hearing impairment are rare but possible.

Contraindications

• Tadalafil should not be combined with nitrates (e.g., nitroglycerin) due to potential severe hypotension.
• It is contraindicated for individuals with severe heart conditions or those who have experienced recent myocardial infarction or stroke.