Anfarm Hellas Clomiphene Citrate 24 tabs (50 mg/tab)

Clomiphene Citrate – Clomid

Clomiphene Citrate, commonly known as Clomid, is a non-steroidal synthetic medication resembling estrogen in structure. It serves widely as an ovulatory stimulant, binding to estrogen receptors in the hypothalamus and deceiving it into believing that “real” estrogen is absent. This stimulates the pituitary gland to release increased levels of Gonadotropins, including FSH and LH, which in turn promotes ovarian/testicular production of estrogen/testosterone.

This characteristic of clomiphene is pivotal for treating women with ovarian failure and fostering ovulation. However, prolonged use may raise concerns regarding the risk of ovarian cancer.

Pharmacology

Clomid is essential for women facing ovulatory dysfunction, often seen in conditions like polycystic ovarian syndrome and unexplained amenorrhea. A comprehensive evaluation of the menstrual cycle is crucial before it’s prescribed. Monitoring body temperature and blood work is vital to confirm ovulation timing.

Clomid typically initiates treatment on the 5th cycle day, with a duration of 3-6 cycles, as long-term use isn’t advocated.

Mode of Action

This powerful medication mimics estrogen, interacting with hypothalamic receptors and leading the brain to perceive low estrone levels. Consequently, it triggers gonadotropin release, stimulating ovaries to enhance estrogen synthesis, which is vital for fertilization.

Indications

Clomid is appropriate for women with ovulatory dysfunction who meet these criteria:

• Not pregnant at therapy initiation
• No presence of ovarian cysts confirmed by ultrasound
• No vaginal bleeding; a thorough examination must rule out cancer
• Normal liver function tests
• Though primarily for female infertility, Clomid has been attempted in males, showing potential in increasing LH and FSH, thereby enhancing sperm count, yet long-term use poses risks such as testicular tumors.
• Prescription dosage guidelines for infertility apply.

As a large, odorless molecule, clomiphene is soluble in various organic solvents and available in 50 mg tablets. Patients must undergo thorough evaluations for gyno-endocrine disorders before treatment begins. Ovulation usually occurs 5-10 days after commencement of Clomid, with coitus timed to maximize chances of conception.

Initial dosing starts at 50 mg/day for 5 days, adjustable for non-responders.

Body Building

Among athletes, Clomid is frequently misused along with anabolic steroids, HCG, and others. Unlike traditional anabolic agents, Clomid stimulates LH release, boosting testosterone levels without suppression.

While most anabolic steroids possess androgenic and anabolic properties, they may convert to estrogen in fatty tissue, leading to gynecomastia. Clomid’s role here is to block estrogen receptors, mitigating unwanted breast development.

Additionally, Clomid enhances sex hormone synthesis and testosterone production through its action on the hypothalamus, making it appealing to bodybuilders. Some may opt for Clomid solely for its anabolic effects, while others combine it with steroid regimens.

Clomid Dosage for Athletes

Typically administered once daily, bodybuilders might utilize Clomid alone or alongside low-potency anabolic steroids. It’s common to switch from anabolic steroids to Clomid 7-10 days post-steroid cycle for maximizing testosterone surges and preventing gynecomastia. Doses usually range from 50-100 mg/day over two weeks, with recommendations to stop after three weeks to align with proven cycling practices.

The long-term impact of Clomid remains undetermined; thus, prolonged usage is discouraged.

Side Effects

Generally safe at recommended dosages, Clomid’s side effects are mostly temporary, resolving after cessation of treatment.

Common adverse reactions include:

• Flushing
• Abdominal discomfort
• Nausea/Vomiting
• Breast tenderness
• Headaches
• Abnormal vaginal bleeding
• General fatigue
• Hair loss
• Visual disturbances

Clomid’s action on the brain raises concerns around visual changes due to hypothalamic receptor blockade, potentially resulting in nerve compression, with symptoms ranging from floaters to blurred vision. Though these effects generally emerge after extended use, some cases appear within a week or two. Immediate discontinuation and ophthalmological consultation are advised upon experiencing visual alterations.

Mood Changes

Notably, mood alterations are reported, with some women developing severe psychological symptoms like depression, anxiety, or aggression after prolonged use. Yet, clinical trials indicate these side effects occur in less than 1% of women, with limited information on their prevalence among bodybuilders.

Cost

While requiring a physician’s prescription for infertility treatment, Clomid is often available online without one. Pricing for clomiphene varies, averaging $50-100 for 100 pills (25-50 mg).

Levels

Despite its accessibility, all sporting organizations have banned Clomid in professional athletics. It can be detected in urine for 5-12 days post-use, with sophisticated testing capable of identifying testosterone and estrogen levels and their ratios, raising red flags for potential misuse.